Hilkka Soininen Selected Research

Apolipoproteins E (ApoE)

1/2022	Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease.
1/2022	Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum.
1/2021	Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
1/2020	Long-term dementia risk prediction by the LIBRA score: A 30-year follow-up of the CAIDE study.
1/2020	Detecting Amyloid Positivity in Elderly With Increased Risk of Cognitive Decline.
1/2019	Prediction models for dementia and neuropathology in the oldest old: the Vantaa 85+ cohort study.
1/2019	Predicting Development of Alzheimer's Disease in Patients with Shunted Idiopathic Normal Pressure Hydrocephalus.
1/2019	Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype.
10/2018	Decreased plasma C-reactive protein levels in APOE ε4 allele carriers.
1/2018	Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial.

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Hilkka Soininen Research Topics

Disease

189	Alzheimer Disease (Alzheimer's Disease) 04/2024 - 03/2000
72	Dementia (Dementias) 03/2022 - 01/2002
66	Cognitive Dysfunction 10/2022 - 09/2004
29	Atrophy 01/2023 - 02/2005
14	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 11/2002
11	Disease Progression 01/2021 - 10/2009
10	Amyloid Plaque 01/2022 - 01/2002
9	Inflammation (Inflammations) 01/2023 - 10/2008
9	Normal Pressure Hydrocephalus 01/2019 - 11/2012
6	Parkinson Disease (Parkinson's Disease) 12/2017 - 01/2003
5	Genetic Risk Score 04/2024 - 01/2015
4	Tauopathies 01/2022 - 01/2011
4	Insulin Resistance 01/2020 - 06/2012
4	Frontotemporal Dementia (Semantic Dementia) 01/2019 - 07/2009
3	Synucleinopathies 01/2022 - 01/2008
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022 - 04/2017
3	Down Syndrome (Down's Syndrome) 10/2021 - 01/2014
3	Infarction (Infarctions) 01/2019 - 02/2008
3	Memory Disorders (Memory Loss) 11/2018 - 01/2013
3	Neuroblastoma 06/2013 - 12/2009
3	Brain Diseases (Brain Disorder) 01/2013 - 01/2012
3	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 11/2012 - 02/2008
3	Hypertension (High Blood Pressure) 01/2011 - 01/2002
2	Type 2 Diabetes Mellitus (MODY) 01/2020 - 06/2014
2	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2019 - 02/2008
2	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 01/2019 - 02/2012
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2018 - 03/2016
2	Genetic Predisposition to Disease (Genetic Predisposition) 01/2018 - 09/2014
2	Hypoxia (Hypoxemia) 01/2017 - 08/2015
2	Skin Neoplasms (Skin Cancer) 11/2015 - 11/2012
2	Obesity 01/2014 - 10/2005
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2012 - 08/2011
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022
1	Hypercholesterolemia 01/2021

Drug/Important Bio-Agent (IBA)

80	Biomarkers (Surrogate Marker)IBA 11/2022 - 04/2005
65	Amyloid (Amyloid Fibrils)IBA 01/2023 - 04/2005
47	Apolipoproteins E (ApoE)IBA 01/2022 - 08/2002
33	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2003
24	ApolipoproteinsIBA 04/2024 - 08/2002
14	Peptides (Polypeptides)IBA 01/2019 - 03/2000
11	CholesterolIBA 01/2022 - 01/2002
11	tau Proteins (tau Protein)IBA 01/2022 - 11/2002
11	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 11/2015 - 12/2009
10	Pemetrexed (MTA)FDA Link 01/2023 - 02/2005
10	Amyloid beta-PeptidesIBA 11/2022 - 09/2007
8	LipidsIBA 09/2019 - 01/2002
5	Apolipoprotein E4IBA 04/2024 - 09/2004
5	CalciumIBA 08/2015 - 02/2008
5	EnzymesIBA 01/2014 - 06/2008
4	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2008
4	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2015 - 02/2009
4	Blood Proteins (Serum Proteins)IBA 11/2014 - 07/2010
3	Fortasyn ConnectIBA 01/2021 - 12/2017
3	DNA (Deoxyribonucleic Acid)IBA 11/2020 - 02/2011
3	Insulin (Novolin)FDA Link 01/2020 - 06/2012
3	Hormones (Hormone)IBA 04/2017 - 01/2014
3	Phosphatidylcholines (Phosphatidylcholine)IBA 01/2017 - 01/2014
3	Presenilin-1IBA 06/2013 - 03/2011
3	ButyrylcholinesteraseIBA 08/2009 - 04/2008
3	Donepezil (Aricept)FDA LinkGeneric 12/2007 - 01/2003
2	ethyl 4-azidophenyl-1,4-dithiobutyrimidateIBA 01/2023 - 11/2022
2	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2021 - 10/2008
2	C-Reactive ProteinIBA 01/2019 - 10/2018
2	Lipoproteins (Lipoprotein)IBA 01/2019 - 10/2016
2	Glycoproteins (Glycoprotein)IBA 01/2019 - 10/2008
2	SynucleinsIBA 01/2019 - 01/2008
2	Carrier Proteins (Binding Protein)IBA 01/2019 - 01/2013
2	FatsIBA 11/2018 - 12/2008
2	IronIBA 01/2017 - 02/2008
2	Complement System Proteins (Complement)IBA 01/2016 - 08/2012
2	BMS 708163IBA 11/2015 - 11/2012
2	pleiotrophin (HARP)IBA 07/2015 - 02/2015
2	Opioid Receptors (Opioid Receptor)IBA 01/2015 - 06/2011
2	Cholinergic Agents (Cholinergics)IBA 01/2015 - 11/2011
2	ClusterinIBA 11/2014 - 07/2010
2	AntioxidantsIBA 01/2014 - 12/2013
2	TocotrienolsIBA 12/2013 - 10/2012
2	Vitamin E FDA LinkGeneric 12/2013 - 10/2012
2	Tocopherols (Tocopherol)IBA 12/2013 - 10/2012
2	GranulinsIBA 01/2013 - 07/2009
2	CytokinesIBA 01/2013 - 01/2011
2	UbiquitinIBA 01/2012 - 11/2005
2	Antihypertensive Agents (Antihypertensives)IBA 01/2011 - 01/2002
2	Dietary Fats (Dietary Fat)IBA 12/2008 - 07/2008
2	Insulysin (Insulin-Degrading Enzyme)IBA 06/2008 - 09/2007
1	antineoplaston A10 (A 10)IBA 01/2022
1	sharpinIBA 01/2021
1	27-hydroxycholesterolIBA 01/2021
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 01/2021
1	OxysterolsIBA 01/2021
1	KynurenineIBA 01/2021
1	Glial Fibrillary Acidic ProteinIBA 01/2021
1	Serotonin (5 Hydroxytryptamine)IBA 01/2021
1	Tryptophan (L-Tryptophan)FDA Link 01/2021
1	C-PeptideIBA 01/2020

Therapy/Procedure

9	Therapeutics 04/2017 - 01/2009
5	Cognitive Training 03/2022 - 06/2015
4	Activities of Daily Living (ADL) 08/2013 - 01/2004
3	Transcranial Magnetic Stimulation 01/2011 - 07/2008
2	Cerebrospinal Fluid Shunts 12/2017 - 01/2013